This study generates human monoclonal antibodies against H5N1 clade 2.3.4.4b HA, identifying four that neutralize the virus in vitro and show protective effects in mice.

Nature Communications · Dec 13, 2025Peer-reviewedMicrobiology

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies

Alexandra A. M. Fischer, Martin Corcoran, Philip J. M. Brouwer, Mark Chernyshev, Rebecca A. Gillespie, Andrea Nicoletto, Johannes R. Loeffler, James A. Ferguson, Alesandra J. Rodriguez, Sanjana Narang, Marit J. van Gils, Xaquín Castro Dopico, Masaru Kanekiyo, Andrew B. Ward, Julianna Han, Gunilla B. Karlsson Hedestam

The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.

bioRxiv · Jul 4, 2025 · PreprintImmunology

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

George Ueda, Aleksandar Antanasijevic, Jorge A. Fallas, William Sheffler, Jeffrey Copps, Daniel Ellis, Geoffrey B. Hutchinson, Adam P. Moyer, Anila Yasmeen, Yaroslav Tsybovsky, Young‐Jun Park, Matthew J. Bick, Banumathi Sankaran, Rebecca A. Gillespie, Philip J. M. Brouwer, , David A. Baker

Designed trimers matched to viral glycoprotein termini yielded tetrahedral, octahedral and icosahedral nanoparticles with cryo-EM-verified structures that display native-like HIV Env, influenza HA and RSV F.

eLife · Aug 3, 2020Peer-reviewedSynthetic Biology✦ In-depth digest