Julianna Han

Convergent antigenic drift of the influenza hemagglutinin lateral patch across time and species

The paper analyzes antigenic drift in the H1 hemagglutinin lateral patch across time and species using monoclonal antibodies to identify mutations that evade immune targeting.

A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins

This paper evaluates a low-dose inactivated split virus vaccine against H5N1 influenza, showing cross-protective immunity against multiple clades in a mouse model.

Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15

The paper characterizes antigenic differences in H15 influenza virus hemagglutinin by analyzing mAb binding and neutralization against ancestral and drifted strains.

Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin

This study generates human monoclonal antibodies against H5N1 clade 2.3.4.4b HA, identifying four that neutralize the virus in vitro and show protective effects in mice.

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryoEM

This paper develops a method to discover monoclonal antibodies directly from immune sera using cryoEM and computational tools, significantly speeding up the process and improving accuracy.

Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3

This study identifies a conserved DR motif in CDR H3 of antibodies targeting the influenza virus neuraminidase active site, suggesting a common strategy for broad protection.

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies

The paper shows that genetic variation in human immunoglobulin genes affects antibody responses to influenza HA, informing vaccine design to cover diverse populations.

Characterization of the glycoproteins of novel fish influenza B-like viruses

The paper characterizes glycoproteins of novel fish influenza B-like viruses, revealing differences in receptor binding and antigenic conservation compared to influenza B viruses.

Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection

The paper uses nsEMPEM to analyze polyclonal IgG responses to HA in vaccinated and infected individuals, showing differences in epitope targeting between H1 and H3 subtypes.

A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth

This study identifies a single mutation in H5N1 viruses from dairy cows that increases receptor binding breadth to avian receptors, suggesting potential for expanded host range.