Mona Sadek Ali

The paper identifies an IL-6-associated SAA axis linked to muscle wasting and poor survival in cancer cachexia through plasma proteomics and functional studies.

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

This study shows that housing temperature affects molecular and systemic responses to cancer in mice, influencing metabolic adaptations and cytokine levels.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

This study identifies Rac1 as a key regulator of exercise training adaptations by showing its role in protein synthesis, glycogen resynthesis, and running capacity in mice and human muscle.

This study shows that AMPK is upregulated in human cachectic muscle and that AMPK deficiency in mice worsens cancer-induced metabolic dysfunction and cachexia.