Andrea Irazoki

The paper identifies an IL-6-associated SAA axis linked to muscle wasting and poor survival in cancer cachexia through plasma proteomics and functional studies.

The paper identifies proteomic and phosphoproteomic changes in skeletal muscle of lung cancer patients with cachexia, linking them to muscle wasting and signaling pathways.

The paper investigates muscle remodeling in NSCLC patients, identifying changes in fibro-adipogenic progenitors, mitochondrial function, and immune cells that contribute to muscle wasting.

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

This study shows that housing temperature affects molecular and systemic responses to cancer in mice, influencing metabolic adaptations and cytokine levels.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.