A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis
Mohammed Rizwan Babu Sait, Lana H. Jachmann, Gözde Türköz, Milica Milivojevic, Celia Llorente-Sáez, Soniya Dhanjal, Fabian Schumacher, Sara Henriksson, Naga Venkata Gayathri Vegesna, Noha Seddik, Anastasiia Chaban, Partha Mohanty, Magnus Ölander, Samada Muraleedharan, Sepideh Farmand Azadeh, , Barbara Susanne Sixt
The paper identifies CpoS as a key effector for maintaining Chlamydia trachomatis vacuole integrity by regulating sphingolipid supply and shows that disrupting this pathway can clear infection without harming host cells.
PLoS Biology · Aug 12, 2025Peer-reviewedMicrobiology