Anita Pirchheim

Acid phospholipase A1 promotes lysosomal membrane catabolism

This study identifies acid phospholipase A1's role in lysosomal glycerophospholipid catabolism and shows its interaction with bis(monoacylglycero)phosphate and inhibition by cationic amphiphilic drugs.

CLN8 enables a non-canonical phospholipid synthesis pathway

The paper describes a non-canonical phospholipid synthesis pathway catalyzed by CLN8, leading to BMP synthesis and revealing its role in lysosomal lipid homeostasis and Batten disease.

White adipose tissue browning preserves UCP1-dependent nonshivering thermogenesis upon brown-adipocyte specific lipase-deficiency

The paper shows that browning of white adipose tissue maintains UCP1-dependent thermogenesis despite loss of lipases in brown adipocytes.

The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways

This study identifies cytosolic and secreted transacylases that synthesize bis(monoacylglycero)phosphate (BMP) independently of CLN5, correcting BMP deficiency in CLN5-deficient cells.

Global analysis of protein arginine methylation

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.