Author

Gian D van der Spuy

South African Medical Research CouncilORCID 0000-0002-9067-5903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1

Frequent Co-Authors

Gerard C. TrompiD· 3 shared Marlo MölleriD· 3 shared Caitlin UreniD· 2 shared Gerald van EedeniD· 2 shared Abhinav SharmaiD· 1 shared Birgit Muntau· 1 shared Brenna M. HenniD· 1 shared Christian G. MeyeriD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersGenetics

Gerard C. TrompORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MTBseq-nf: Enabling Scalable Tuberculosis Genomics "Big Data" Analysis through a User-Friendly Nextflow Wrapper for MTBseq pipeline

Abhinav Sharma, Davi Josué Marcon, Johannes Loubser, Karla Valéria Batista Lima, Gian D van der Spuy, Emilyn Costa Conceição

The paper introduces MTBseq-nf, a Nextflow wrapper for the MTBseq pipeline, improving scalability and efficiency for tuberculosis genomics analysis.

Microorganisms · Nov 25, 2025Peer-reviewedBioinformatics

GWAS in the Southern African context

Yolandi Swart, Gerald van Eeden, Caitlin Uren, Gian D van der Spuy, Gerard C. Tromp, Marlo Möller

The paper evaluates the performance of the LAAA model in detecting causal variants in complex admixed southern African populations and recommends using multiple GWAS models.

PLoS ONE · Sep 28, 2022Peer-reviewedGenetics

The Recombination Landscape of the Khoe-San - the Upper Limits of Recombination Divergence in Humans

Gerald van Eeden, Caitlin Uren, Evlyn Pless, Mira Mastoras, Gian D van der Spuy, Gerard C. Tromp, Brenna M. Henn, Marlo Möller

The paper infers the demographic history of the Nama population and constructs a population-specific recombination map, showing it diverges from existing continental recombination maps.

bioRxiv · Nov 7, 2021 · PreprintBioinformatics

A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort

Stéphanie Muller, Haiko Schurz, Gerard C. Tromp, Gian D van der Spuy, Eileen Garner Hoal, Paul D. van Helden, Ellis Owusu‐Dabo, Christian G. Meyer, Birgit Muntau, Thorsten Thye, Stefan Niemann, Robin M. Warren, Elizabeth Maria Streicher, Marlo Möller, Craig John Kinnear

This study performs a genome-wide association analysis of host genetic variants and MTBC strain infection in two cohorts, identifying 32 SNPs significantly associated with infection risk in the Ghanaian cohort.

Genomics · Apr 20, 2021Peer-reviewedGenetic & Genomic Medicine