Brent Myers

Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry

This study examines sex-specific differences in prefrontal-hypothalamic circuitry in rats, revealing sex differences in neuronal excitability, synaptic connectivity, and stress-activated neurons.

Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats

This study shows that the IL-RVLM circuit is essential for sex-specific glucose homeostasis under chronic stress in rats.

Infralimbic prefrontal cortical projections to the autonomic brainstem: Quantification of inputs to cholinergic and adrenergic/noradrenergic nuclei

This study quantifies infralimbic cortical projections to autonomic brainstem nuclei in rats, revealing differential targeting of cholinergic and adrenergic/noradrenergic regions.

Repeated presentation of visual threats drives innate fear habituation and is modulated by environmental and physiological factors

This study shows that repeated visual threat exposure leads to fear habituation in mice, influenced by inter-trial intervals and physiological stress.

Sex-Specific Cardiac Remodeling in Aged Rats after Early-Life Chronic Stress: Associations with Endocrine and Metabolic Factors

This study examines sex-specific cardiac remodeling in aged rats exposed to early-life chronic stress, finding females show greater left ventricular hypertrophy while males exhibit varied associations with endocrine and metabolic factors.

Cortical-brainstem circuitry attenuates physiological stress reactivity

This study identifies a direct vmPFC-RVLM circuit that reduces endocrine stress responses by recruiting inhibitory neurons in the medulla, with effects observed in both male and female rats.

Sex-specific prefrontal-hypothalamic control of behavior and stress responding

This study investigates sex-specific roles of the vmPFC-PH circuit in regulating stress responses and behavior in rats using optogenetics and genetic approaches.

Prefrontal representation of affective stimuli: importance of stress, sex, and context

This study investigates how chronic stress affects neural processing of affective stimuli in the vmPFC of male and female rats, revealing sex-dependent and context-specific changes.

Sexually divergent cortical control of affective-autonomic integration

This study investigates sex differences in how the infralimbic prefrontal cortex regulates stress responses and cardiovascular outcomes in rodents.

Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress

This study shows that reducing glutamate output in the infralimbic cortex of rats alters neural activity and behavior after chronic stress, highlighting its role in stress-related disorders.

Prefrontal Cortex Regulates Chronic Stress-Induced Cardiovascular Susceptibility

This study shows that reducing glutamate release from infralimbic cortex neurons increases cardiovascular reactivity and vascular dysfunction under chronic stress.