Translocation of HIV capsid core through the Nuclear Pore Complex by affinity gradient
Ivo Melčák, Ryan L. Slack, Zachary C. Lorson, Andres Emanuelli Castaner, Krisztina Ambrus, Jonathan S. Winkjer, Karen A. Kirby, Robert A. Dick, Stefan G. Sarafianos
This paper investigates how HIV capsid core translocates through the Nuclear Pore Complex by analyzing FG repeat interactions and identifies an affinity gradient that facilitates unidirectional translocation.
bioRxiv · Oct 2, 2025 · PreprintMicrobiology