Zachary C. Lorson

The paper characterizes structural, biophysical, and virological properties of HIV-1 capsid-targeting antivirals, showing improved potency and stability through chemical modifications of PF74.

This study investigates how ZW-1261, an FGBP-targeting inhibitor, disrupts HIV-1 capsid morphology by affecting pentameric subunits and core closure.

This paper designs and synthesizes LEN analogs with improved potency against HIV-1 and resistant variants like M66I, showing significant enhancement in antiviral activity.

This paper investigates how HIV capsid core translocates through the Nuclear Pore Complex by analyzing FG repeat interactions and identifies an affinity gradient that facilitates unidirectional translocation.

This paper optimizes Bio-Layer Interferometry (BLI) protocols to measure binding affinities of antiviral compounds with viral proteins, demonstrating sub-nanomolar KD values and covalent interactions.