Scott V. Dindot

The paper evaluates delta power abnormalities in a maternal UBE3A-deletion pig model of Angelman syndrome using EEG, finding elevated delta power during wakefulness and reduced transitions to sleep.

The paper uses single nuclei RNA-sequencing to identify cell-type-specific gene expression dysregulation in the frontal cortex of an Angelman syndrome pig model.

This paper develops a Splint-Ligation PCR assay to quantify antisense oligonucleotides in non-human primate CNS tissues and biofluids, showing high sensitivity and broad dynamic range.

This study quantifies CNS tissue and CSF volumes in developing pigs using MRI, revealing age-related changes in CSF distribution.

This paper describes a pig model of Angelman syndrome that mirrors early developmental symptoms observed in humans.

This paper describes the development of an antisense oligonucleotide (ASO) therapy targeting the UBE3A-AS transcript to reactivate paternal UBE3A expression in Angelman syndrome models.