Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.
Sujan Chetterjee, Zachary Sin, Richard Van, Nguyen Tran, Tam Tran, Anuj Shukla, Lucile M. Jeusset, George Koshkaryan, Kevin Saldana, Rayan Muneer, Loretta Viera Preval, Lingkun Gu, Faizan Bhat, Kevin Ritter, Katherine Huang, , Prasun Guha
The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.
bioRxiv · May 27, 2026 · PreprintCell Biology