Author

Zachary Sin

University of Nevada, Las VegasORCID 0009-0001-7734-5192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Assay:proteomics· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Henning Jacob JesseniD· 3 shared Kevin RitteriD· 3 shared Loretta Viera Preval· 3 shared Nguyen Tran· 3 shared Prasun GuhaiD· 3 shared Anas K. Gremida· 2 shared Anuj Shukla· 2 shared George Koshkaryan· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Henning Jacob JessenORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 27, 2026

Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.

Sujan Chetterjee, Zachary Sin, Richard Van…·Prasun Guha

The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.

DOI 10.64898/2026.05.24.727426

mouseproteomics

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Cell BiologyNature CommunicationsPeer-reviewedFeb 9, 2026

Phytic Acid (InsP6) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function

Sujan Chatterjee, Zachary Sin, Nguyen Tran…·Prasun Guha

The paper shows that phytic acid activates the HDAC3 epigenetic axis to maintain intestinal barrier function, with therapeutic potential in inflammatory bowel disease.

8 citationstop 4%

humanDNA methylation

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Cell BiologyAging CellPeer-reviewedJul 15, 2025

βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells

Sujan Chatterjee, Sayan Ghosh, Zachary Sin…·Prasun Guha

The paper identifies βA3/A1-crystallin as an epigenetic regulator of HDAC3 in RPE cells, showing it enhances HDAC3 activity through CK2 interaction and InsP6 regulation, linking it to AMD pathogenesis.

6 citations

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