Joses Ho

Getting over ANOVA: Estimation graphics for multi-group comparisons

The paper introduces DABEST 2.0, an estimation framework for multi-group comparisons in experimental science, focusing on effect-size quantification instead of null-hypothesis significance testing.

Contextualized phenovectors reveal a Drosophila serotonergic circuit controlling satiety

The paper uses a contextualized ethomics approach to show that Trhn serotonergic neurons in Drosophila control satiety, while other circuits only produce fragmented behavioral changes.

A mushroom-body output neuron that mediates octopamine-driven and hunger-motivated feeding in Drosophila

The paper identifies a mushroom-body output neuron (MBON11) that mediates octopamine-driven and hunger-motivated feeding in Drosophila through synaptic connections with specific neuromodulatory neurons.

Automated leg tracking reveals distinct conserved gait and tremor signatures in Drosophila models of Parkinson’s Disease and Spinocerebellar ataxia 3

The paper develops FLLIT, a machine-learning tool for automated leg tracking in Drosophila, revealing distinct gait and tremor signatures in PD and SCA3 models.

Moving beyond P values: Everyday data analysis with estimation plots

The paper advocates for using estimation plots over p-values for data analysis and presents the DABEST tool for creating these plots.

The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors

This study investigates the impact of the Drosophila microbiome on sleep, activity, and courtship behaviors, finding limited influence.

Optical inhibition of zebrafish behavior with anion channelrhodopsins

This study tests the use of GtACR1 and GtACR2 anion channelrhodopsins in zebrafish to optically inhibit neurons and assess neural circuit necessity.

Potent optogenetic inhibition of behavior with anion channelrhodopsins

The paper demonstrates that anion channelrhodopsins can effectively inhibit various behaviors in Drosophila, highlighting their utility in circuit analysis.

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

This study reviews and meta-analyzes rodent anxiety models to assess the effects of various interventions, finding eight had significant effects, while others showed discordance or publication bias.