Adam Claridge‐Chang

Getting over ANOVA: Estimation graphics for multi-group comparisons

The paper introduces DABEST 2.0, an estimation framework for multi-group comparisons in experimental science, focusing on effect-size quantification instead of null-hypothesis significance testing.

Contextualized phenovectors reveal a Drosophila serotonergic circuit controlling satiety

The paper uses a contextualized ethomics approach to show that Trhn serotonergic neurons in Drosophila control satiety, while other circuits only produce fragmented behavioral changes.

Long-Stokes-Shift mScarlet3 as a Structural Marker for Two-Photon Imaging

The paper introduces a long-Stokes-shift mScarlet variant for two-photon imaging, enabling simultaneous imaging with green sensors using a single laser.

Brief illumination of an optoGPCR elicits prolonged inhibition of Drosophila behavior

The paper tests optoGPCRs in Drosophila, finding MosOPN3 provides effective, low-toxicity inhibition with brief light pulses.

A mushroom-body output neuron that mediates octopamine-driven and hunger-motivated feeding in Drosophila

The paper identifies a mushroom-body output neuron (MBON11) that mediates octopamine-driven and hunger-motivated feeding in Drosophila through synaptic connections with specific neuromodulatory neurons.

Two-photon characterisation of long-Stokes-shift dye ATTO 490LS for single-laser multicolour imaging

The paper characterizes the two-photon properties of ATTO 490LS and demonstrates its use in multicolour two-photon imaging with a single laser.

Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins

The paper identifies a KCR1 variant, C29D, that maintains stable potassium selectivity and provides reliable optogenetic inhibition across species and conditions.

Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons

The paper shows that optogenetic activation of sensory and dopaminergic neurons can induce synthetic associative memories in vinegar flies, demonstrating that simple coincident stimulation is sufficient for memory formation.

Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments

The paper presents a chromosome-scale genome assembly of Alvinella pompejana and analyzes its gene content to understand adaptations to extreme environments.

Kalium channelrhodopsins effectively inhibit neurons in the small model animals

This study evaluates kalium channelrhodopsins (KCRs) as optogenetic inhibitors in Drosophila, C. elegans, and zebrafish, showing they are effective and have improved properties compared to chloride-conducting ACRs.

Contingent-behavior assay to study the neurogenetics of addiction shows zebrafish preference for alcohol is biphasic

The paper develops a zebrafish assay to study alcohol preference, finding a biphasic response where low alcohol concentrations are attractive and high concentrations are avoided.

Characterization of induction methods for Drosophila seizure mutations

The paper compares seizure-induction methods in Drosophila to identify the most effective for studying seizure-prone mutants.

NEURONS THAT FUNCTION WITHIN AN INTEGRATOR TO PROMOTE A PERSISTENT BEHAVIORAL STATE IN DROSOPHILA

The paper identifies pCd neurons in Drosophila that integrate P1 input to promote persistent behavioral states related to courtship and aggression.

Automated leg tracking reveals distinct conserved gait and tremor signatures in Drosophila models of Parkinson’s Disease and Spinocerebellar ataxia 3

The paper develops FLLIT, a machine-learning tool for automated leg tracking in Drosophila, revealing distinct gait and tremor signatures in PD and SCA3 models.

Moving beyond P values: Everyday data analysis with estimation plots

The paper advocates for using estimation plots over p-values for data analysis and presents the DABEST tool for creating these plots.

Motor context coordinates visually guided walking in Drosophila

The paper investigates how motor context influences visual feedback's role in course control during exploratory walking in Drosophila using Virtual Reality.

Optogenetic olfactory behavior depends on illumination characteristics

This study shows that optogenetic-induced olfactory behaviors in Drosophila depend on light intensity and oscillation frequency, highlighting the need for varied illumination regimes in experiments.

A zinc-finger fusion protein refines Gal4-defined neural circuits

The paper introduces a zinc-finger fusion protein to refine Gal4-defined neural circuits by creating an intersectional genetic AND operator for more precise cell-type targeting.

The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors

This study investigates the impact of the Drosophila microbiome on sleep, activity, and courtship behaviors, finding limited influence.

Optical inhibition of zebrafish behavior with anion channelrhodopsins

This study tests the use of GtACR1 and GtACR2 anion channelrhodopsins in zebrafish to optically inhibit neurons and assess neural circuit necessity.

Potent optogenetic inhibition of behavior with anion channelrhodopsins

The paper demonstrates that anion channelrhodopsins can effectively inhibit various behaviors in Drosophila, highlighting their utility in circuit analysis.