Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and prevent cell senescence.
Yue Xu, Ziyi Wang, Wenxin Feng, Hanyu Rao, Dehuan Wang, Wei Zhang, Rebiguli Aji, Ningyuan Liu, Wei‐Qiang Gao, Li Li
This study shows that H3K36me3, catalyzed by SETD2, maintains ISC stemness by regulating lipid metabolism and preventing senescence through chromatin remodeling and metabolic intervention.
bioRxiv · Apr 9, 2025 · PreprintCell Biology