Wei‐Qiang Gao

This study shows that NSD2 deficiency disrupts chromatin accessibility and gene expression in cochlear hair cells, leading to increased ECM expression and hearing impairment, which can be mitigated by ECM intervention.

This study shows NSD2 promotes cell durotaxis and drives the transition from PKD to TCRCC via integrin/FAK/AKT signaling, with implications for targeted therapies.

This study shows that H3K36me3, catalyzed by SETD2, maintains ISC stemness by regulating lipid metabolism and preventing senescence through chromatin remodeling and metabolic intervention.

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

This study shows that SETD2 deficiency promotes renal fibrosis by activating the TGF-β/Smad signaling pathway in VHL-deficient mice.

The paper identifies a basal stem cell subpopulation in the prostate using lineage tracing, functional analysis, and single-cell RNA-seq, showing Zeb1+ cells are multipotent prostate basal stem cells.

This study shows that E-cadherin connects cell polarity and spindle orientation in prostate epithelial cells, preventing carcinogenesis.

This study shows that PRL-1 is necessary for neuroprotection against CO2-induced brain disorders in Drosophila by regulating neural circuits and molecular interactions.