Jessica A. Lehoczky

This study identifies the pituitary as a conserved regulator of regeneration across vertebrates, showing its role in limb and fin regeneration through prolactin and growth hormone signaling.

This study uses single-cell RNA sequencing to identify fibroblast subpopulations and genes linked to fibrosis and regeneration, then tests their effects using AAV gene delivery in mouse digits.

The paper shows Mest expression in mouse digit regeneration is regulated by promoter switching, not imprinting, and modulates neutrophil response.

This study investigates whether En1 and Lmx1b, which are critical for DV patterning during limb development, also regulate DV patterning during mouse digit tip regeneration, finding they do not.

This study shows LGR6 is essential for osteoblast proliferation, differentiation, and peak bone mass, with distinct signaling roles for its ligands RSPO2 and MaR1.

The paper uses single-cell RNA sequencing to analyze mouse digit tip blastema cells, identifying lineage-restricted progenitors and a novel regeneration-specific gene, Mest.