Carol W. Greider

This paper introduces a method using Oxford Nanopore long-read sequencing to measure chromosome-specific telomere lengths in human cells.

The paper presents T2T reference genomes from a multi-generational pedigree to study genetic and epigenetic inheritance across the complete genome.

The paper develops a nanopore sequencing method to measure telomere length and finds chromosome-specific and conserved telomere lengths across individuals.

The paper validates novel telomere length regulation genes POP5 and KBTBD6 identified through trans-ancestry GWAS using functional experiments in blood cells.

The paper develops a nanopore sequencing method to measure chromosome-specific telomere lengths in yeast, revealing stable lengths and new insights into telomere regulation.

The paper identifies a domain in Rif1 containing HEAT repeats that regulates telomere length independently of its proposed DNA-binding function.

The paper investigates whether telomere length regulation by Rif1 is linked to telomeric origin firing, finding they are separable functions.

The paper shows that Tel1 activation by the MRX complex regulates telomere length but not the DNA damage response in S. cerevisiae, challenging existing models.

This study identifies a new TIN2 isoform, TIN2M, and shows that all TIN2 isoforms enhance telomerase processivity beyond TPP1/POT1, suggesting TIN2 is a functional component of the TPP1/POT1 complex.

This study evaluates the diagnostic and prognostic value of telomere length measurement in a hospital setting, finding it alters treatment decisions in a subset of bone marrow failure patients.

This study identifies BRD4 as a telomere length regulator and shows that BRD4 inhibitors block telomere elongation in mouse and human cells.