The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.

Science Advances · Feb 28, 2025Peer-reviewedCell Biology

TIN2 functions with TPP1/POT1 to stimulate telomerase processivity

Alexandra M. Pike, Margaret A. Strong, John Paul T. Ouyang, Carla J. Connelly, Carol W. Greider

This study identifies a new TIN2 isoform, TIN2M, and shows that all TIN2 isoforms enhance telomerase processivity beyond TPP1/POT1, suggesting TIN2 is a functional component of the TPP1/POT1 complex.

Molecular and Cellular Biology · Aug 5, 2019Peer-reviewedMolecular Biology

Diagnostic utility of telomere length measurement in a hospital setting

Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy Elizabeth Dezern, Susan E. Stanley, Clifford M. Takemoto, Ludmila Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert Alan Brodsky, James F. Casella, Carol W. Greider, J. Brooks Jackson, Mary Y. Armanios

This study evaluates the diagnostic and prognostic value of telomere length measurement in a hospital setting, finding it alters treatment decisions in a subset of bone marrow failure patients.

Proceedings of the National Academy of Sciences · Feb 20, 2018Peer-reviewedGenetics

BRD4 inhibitors block telomere elongation

Steven Wang, Alexandra M. Pike, Stella S. Lee, Margaret A. Strong, Carla J. Connelly, Carol W. Greider

This study identifies BRD4 as a telomere length regulator and shows that BRD4 inhibitors block telomere elongation in mouse and human cells.

Nucleic Acids Research · Jun 22, 2017Peer-reviewedMolecular Biology