Author
Zhejiang UniversityORCID 0000-0002-3172-0540Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Quanyu Chen, Fan Wang, Anguo Liu, Zhengzhang Zhu, Hanyao Wang, Xiaoxiao Li, Dongya Wu, Guojie Zhang
The paper examines copy-number variation in the human pepsinogen A gene across Eurasia, linking it to dietary adaptation and selective pressures.
bioRxiv · Aug 21, 2026 · PreprintGenomics
Ting Yang, Junzhe Shi, Quanyu Chen, Dongya Wu, Xinjiang Tan, Jue Ruan, Chentao Yang
PanSVmerger reduces redundant multiallelic structural variants in pangenome graphs with minimal loss of sensitivity, improving precision and F1-score.
bioRxiv · Aug 18, 2026 · PreprintBioinformatics
Dongya Wu, Chentao Yang, Quanyu Chen, Mingyu Suo, Feifei Zhou, Anguo Liu, Dan Yu, Lei Nie, Ting Yang, Yanqing Sun, Junmin Han, Lili Yang, Qingyang Ni, Di Sun, Yanlin Lu, , Guojie Zhang
The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.
bioRxiv · Jul 28, 2026 · PreprintGenomics
Yanqing Sun, Shijie Wan, Lei Nie, Dan Yu, Feifei Zhou, Yi Yang, Xiangyu Yang, An Liu, Quanyu Chen, Kezhi Fu, Qingyang Ni, Yaoxi He, Bing Su, Yafei Mao, Kai Ye, , Wu Dongya
Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.
bioRxiv · Jul 24, 2026 · PreprintGenomics✦ In-depth digest
Mingyu Suo, Aoyue Bi, Quanyu Chen, Dan Yu, Linghan Jiang, An Liu, Yi Yang, Hanyao Wang, Yanqing Sun, Lei Nie, Ruixue Chen, Qiangzhen Yang, Xiaotao Wang, Haishuai Wang, YongYong SHI, , Guojie Zhang
The paper introduces ASMaid, a method to detect archaic introgression sequences in human genomes, revealing more complete and diverse archaic segments than previous methods.
bioRxiv · Jul 24, 2026 · PreprintEvolutionary Biology
Lingjuan Xie, Yujie Huang, Wei Huang, Lianguang Shang, Yanqing Sun, Quanyu Chen, Shuangtian Bi, Mingyu Suo, Shiyu Zhang, Chentao Yang, Xiaoming Zheng, Weiwei Jin, Qian Qian, Longjiang Fan, Dongya Wu
This study analyzes rice centromeres to understand their genetic diversity and evolution, finding that structural variations and retrotransposon insertions drive centromere innovation.
Nature Genetics · Oct 21, 2025Peer-reviewedGenetics
Quanyu Chen, Chentao Yang, Guojie Zhang, Dongya Wu
GCI evaluates genome assembly continuity at single nucleotide resolution to determine how close an assembly is to T2T standards.
Bioinformatics · Oct 18, 2024Peer-reviewedBioinformatics