Anna Hutchinson

The paper develops a CRISPRi-based single-cell screening approach to map non-coding regulatory elements to genes in primary human CD4+ T cells and demonstrates its utility for GWAS effector gene identification.

The paper introduces an R package called fcfdr that extends the cFDR framework to use binary functional genomic data in GWAS, improving power while controlling FDR, and applies it to type 1 diabetes.

This paper introduces Flexible cFDR, a method that improves GWAS discovery by using auxiliary data from arbitrary distributions to control the false discovery rate and increase sensitivity.

This paper improves the resolution of Bayesian genetic fine-mapping by correcting coverage estimates of credible sets, reducing the number of variants to consider in 27 type 1 diabetes regions.

The paper identifies a causal variant in a super-enhancer that disrupts an NF-κB regulatory circuit, leading to T-cell activation in immune-mediated diseases.