Author

Alavattam Sreedhara

GenentechORCID 0000-0002-9227-2446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

Andrew M. WatkinsiD· 1 shared Bob Kelley· 1 shared Caleigh M. AzumayaiD· 1 shared Cecilia ChiuiD· 1 shared Flaviyan Jerome IrudayanathaniD· 1 shared Franziska SeegeriD· 1 shared Jonathan Zarzar· 1 shared M Rhyan PunoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

Andrew M. WatkinsORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Rational design of oxidation-resistant antibodies through local electrostatic modulation

Sunidhi Lenka, Shrenik C. Mehta, Nicole M. Stephens, Franziska Seeger, Wei‐Ching Liang, Andrew M. Watkins, Jonathan Zarzar, Negar Jafari, M Rhyan Puno, Caleigh M. Azumaya, Ryan L. Kelly, Shuang Wu, Cecilia Chiu, Meredith Hazen, Yan Ting Wu, , Saeed Izadi

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.

bioRxiv · Jun 29, 2025 · PreprintBiochemistry