Author

M Rhyan Puno

GenentechORCID 0000-0001-9653-3220Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Alavattam SreedharaiD· 1 shared Andrew M. WatkinsiD· 1 shared Bob Kelley· 1 shared Caleigh M. AzumayaiD· 1 shared Cecilia ChiuiD· 1 shared Cem MeydaniD· 1 shared Christopher D. LimaiD· 1 shared Christopher E. MasoniD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alavattam SreedharaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 29, 2025

Rational design of oxidation-resistant antibodies through local electrostatic modulation

Sunidhi Lenka, Shrenik C. Mehta, Nicole M. Stephens…·Saeed Izadi

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.

DOI 10.1101/2025.06.29.662139

protein structuremachine learning (classical)

𝕏 PostBluesky

GeneticseLifePeer-reviewedJan 23, 2018

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

Devanshi Jain, M Rhyan Puno, Cem Meydan…·Scott Keeney

The paper identifies YTHDC2 as essential for meiotic progression in mice, showing its role in gene expression transitions and its evolutionary conservation.

155 citationstop 1%

mouseexperimental assay

𝕏 PostBluesky