Flaviyan Jerome Irudayanathan

Systematic assessment of machine learning-based variant annotation methods for rare variant association testing

The paper benchmarks five machine learning-based variant annotation methods for rare variant association testing across 350,377 UK Biobank participants, finding CADD provides best signal separation and GPN-MSA highest enrichment for loss-of-function intolerant genes.

Rational design of oxidation-resistant antibodies through local electrostatic modulation

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.