Cecilia Chiu

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

This paper develops a co-culture assay to measure integrin αvβ8-mediated activation of latent TGF-β1, showing it is sensitive and effective for screening antibodies.

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.