Author

Sunidhi Lenka

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

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Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

Alavattam SreedharaiD· 1 shared Andrew M. WatkinsiD· 1 shared Bob Kelley· 1 shared Caleigh M. AzumayaiD· 1 shared Cecilia ChiuiD· 1 shared Flaviyan Jerome IrudayanathaniD· 1 shared Franziska SeegeriD· 1 shared Jonathan Zarzar· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alavattam SreedharaORCID

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1 paper

Recent·Most cited

Rational design of oxidation-resistant antibodies through local electrostatic modulation

Sunidhi Lenka, Shrenik C. Mehta, Nicole M. Stephens, Franziska Seeger, Wei‐Ching Liang, Andrew M. Watkins, Jonathan Zarzar, Negar Jafari, M Rhyan Puno, Caleigh M. Azumaya, Ryan L. Kelly, Shuang Wu, Cecilia Chiu, Meredith Hazen, Yan Ting Wu, , Saeed Izadi

This paper develops a machine learning model to predict Trp oxidation risk in antibodies and shows that modulating electrostatic potential reduces oxidation while maintaining binding affinity.

bioRxiv · Jun 29, 2025 · PreprintBiochemistry