Single-Cell Super-Resolution Quantification of Oxidative DNA Damage via Aptamer-Assisted DNA-PAINT
Jingfang Zhao, Liu Leo Liu, Yunpeng Song, Yuang Wang, Jingwen Deng, Lisheng Zhang, Yibin Liu, Shuoxing Jiang, Limin Xiang
This paper develops a super-resolution imaging method to quantify oxidative DNA damage at the single-cell level using DNA aptamers and DNA-PAINT, showing improved specificity and resolution over traditional methods.
Analytical Chemistry · Nov 18, 2025Peer-reviewedBiochemistry