This paper develops a super-resolution imaging method to quantify oxidative DNA damage at the single-cell level using DNA aptamers and DNA-PAINT, showing improved specificity and resolution over traditional methods.

Analytical Chemistry · Nov 18, 2025Peer-reviewedBiochemistry

Super-Resolution Diffusivity Mapping Reveals Spatial Correlations Between Lateral Mobility and Structural Heterogeneities on Cellular Membranes

Chu Han, Zhe Zhao, Huihui Gao, Jingwen Deng, Qi Wang, Yihan Wang, Lili Liu, Xu Lin, Shuoxing Jiang, Xiang Zhan, Kun Chen, Rui Yan, Wan Li, Weihua Huang, Ke Xu, Limin Xiang

This study introduces pc-SMdM, a super-resolution technique to map nanoscale diffusivity on cellular membranes, revealing clusters influenced by cholesterol and membrane structure.

bioRxiv · Apr 1, 2025 · PreprintBiophysics

A proteomics sample metadata representation for multiomics integration, and big data analysis.

Chengxin Dai, Anja Füllgrabe, Julianus Pfeuffer, Elizaveta M. Solovyeva, Jingwen Deng, Pablo A Moreno, Selvakumar Kamatchinathan, Deepti J Kundu, Nancy George, Silvie Korena Fexova, Björn Andreas Grüning, Melanie Christine Föll, Johannes Griss, Marc Vaudel, Enrique Audain, , Yasset Pérez‐Riverol

The paper introduces a standardized metadata format for proteomics datasets to improve reusability and integration across public repositories.

Nature Communications · Oct 6, 2021Peer-reviewedBioinformatics