Author

Justin A. MacDonald

University of CalgaryORCID 0000-0002-9238-8473Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Abdulhameed Al‐GhabkariiD· 1 shared Bjoern K Ziehr· 1 shared Bruno C Amaral· 1 shared Christina F. SandalliD· 1 shared David A. Carlson· 1 shared David C Schriemer· 1 shared Timothy HaysteadiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Abdulhameed Al‐GhabkariORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 9, 2026

Mapping the reactive cysteine landscape of the NOD-like receptor pyrin domain-containing 3 protein

Bjoern K Ziehr, Bruno C Amaral, David C Schriemer, Justin A MacDonald

This study identifies reactive cysteine residues in NLRP3 and shows how their oxidation by ROS affects NLRP3 conformation and inflammasome activation.

DOI 10.64898/2026.11.06.764924

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 28, 2025

Molecular dynamics simulations reveal the impact of Ser295 phosphorylation on the structure of pyrin domain-containing NOD-like receptor 3

Christina F. Sandall, Justin A. MacDonald

The paper uses molecular dynamics simulations to show that Ser295 phosphorylation in NLRP3 alters its structure, affecting ATPase activity and inflammasome assembly.

DOI 10.1101/2025.05.28.656610

mechanistic / dynamical modelprotein folding & dynamics

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 6, 2024

Cooperative involvement of zipper-interacting protein kinase (ZIPK) and the dual-specificity cell division cycle 14A phosphatase (CDC14A) in vascular smooth muscle cell migration

Abdulhameed Al‐Ghabkari, David A. Carlson, Timothy Haystead, Justin A. MacDonald

This study identifies ZIPK and CDC14A as regulators of FAK phosphorylation and VSMC migration through their interaction and signaling pathway.

1 citation

humanexperimental assay

𝕏 PostBluesky