Author

Alexandra N. Khristich

Stanford UniversityORCID 0000-0002-9240-5720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Abhishek DuttaiD· 1 shared Dmitri A. PetroviD· 1 shared Jean C. C. VilaiD· 1 shared Jillian F. ArmeniaiD· 1 shared Joseph SchachereriD· 1 shared Liangzi LiiD· 1 shared Marion GariniD· 1 shared Olivia M. GhoshiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

Abhishek DuttaORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintOct 9, 2025

Adaptive evolution can overwrite initial natural fitness variation only in highest-fitness yeast isolates

Alexandra N. Khristich, Olivia M. Ghosh, Jean C. C. Vila…·Dmitri A. Petrov

This study shows that high initial fitness is necessary but not sufficient for long-term success in yeast, as adaptive mutations can override small fitness differences.

1 citation

yeastDNA methylation

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Molecular BiologybioRxivPreprintJun 12, 2024

DNA Nicks Drive Massive Expansions of (GAA)n Repeats

Liangzi Li, W. Shem Scott, Alexandra N. Khristich…·Sergei M. Mirkin

This study shows DNA nicks drive (GAA)n repeat expansions in dividing and non-dividing cells, mimicking human disease mechanisms.

5 citations

humanyeast

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