Olivia M. Ghosh

The paper tests how environmental order affects the fitness of yeast mutants and finds that overall fitness is largely invariant to order due to compensatory history-dependent effects.

This study shows that high initial fitness is necessary but not sufficient for long-term success in yeast, as adaptive mutations can override small fitness differences.

The paper uses yeast mutants to show that fitness can be predicted by low-dimensional genotype-phenotype-fitness maps across environments, supporting a limiting functions model of fitness.

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.