Jean C. C. Vila

Adaptive evolution can overwrite initial natural fitness variation only in highest-fitness yeast isolates

This study shows that high initial fitness is necessary but not sufficient for long-term success in yeast, as adaptive mutations can override small fitness differences.

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

The paper assesses fitness effects of 9,000 natural variants in yeast signaling pathways, finding that many non-neutral variants show signs of local adaptation.