Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis
Yue Zhu, Wanjun Zhang, Qian Li, Mengxue Hu, Xiaoke Xing, Yanze Li, Hemeng Zhang, Yuanyuan Zhao, Luojun Chen, Chunmin Zhang, Yali Chen, Juanjuan Li, Weijie Qin, Suxia Han, Huadong Pei, , Feng Yao
This study identifies PRMT6-mediated arginine methylation of NADK that suppresses its kinase activity and NADP+ synthesis, revealing a regulatory mechanism involving coordination with Akt phosphorylation and implications for cancer progression.
Cell Death and Disease · Sep 3, 2026Peer-reviewedCancer Biology