Dana Pe’er

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.

MAGIC improves single-cell RNA-seq data by imputing missing values and revealing gene-gene interactions through a diffusion-based method.

The paper develops methods to infer dynamic gene regulatory network rewiring during EMT from single-cell data and validates their predictive power for drug effects.

The paper proposes the Human Cell Atlas project to catalog all human cell types through molecular profiling and connects this data with classical cellular descriptions.