Ying-Yi Kuo

The paper investigates how Axin1 and Axin2 regulate WNT signaling to specify distinct mesoderm lineages during gastrulation.

The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

This study identifies SP5 and SP8 as transcription factors that drive primary cilia formation through genetic and transcriptomic analyses in mouse embryos.

This study shows that ETV4 and ETV5 regulate lineage specification and embryo patterning in mice by affecting primitive endoderm formation and pluripotency exit.

The paper uses single-cell RNA and ATAC-seq to study bidirectional reprogramming between embryonic states, revealing differences in lineage plasticity.

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.