Author

Deborah Aubin

The University of SydneyORCID 0009-0007-4139-1676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anai Gonzalez-CorderoiD· 2 shared Guei‐Sheung LiuiD· 2 shared Satheesh KumariD· 2 shared Yi-Wen HsiaoiD· 2 shared Alex William HewittiD· 1 shared Alicia A. BrunetiD· 1 shared Bang Viet BuiiD· 1 shared Chi D. LuuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Anai Gonzalez-CorderoORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 6, 2025

Engineering single-AAV CRISPR-Cas13 RNA base editors for treatment of inherited retinal diseases

Satheesh Kumar, Heng-Ai Chang, Deborah Aubin…·Guei‐Sheung Liu

This paper develops an RNA base editor using CRISPR-Cas13 and ADAR2DD to correct mutations in inherited retinal diseases, showing up to 60% editing efficiency in vitro and partial rescue in mouse models.

DOI 10.1101/2025.08.06.668808

mousehuman

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedOct 30, 2024

Characterisation of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina

Satheesh Kumar, Yi-Wen Hsiao, Vickie H. Y. Wong…·Guei‐Sheung Liu

This study characterizes the transcriptomic effects of Cas13bt3 in retinal cells and demonstrates its efficacy in silencing VEGFA mRNA in human retinal organoids and mouse models.

19 citations

humanmouse

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