Satheesh Kumar

This paper introduces MATCH, a method to engineer AAV tropism by conjugating targeting proteins, achieving efficient transduction of T cells and enhanced brain delivery in vivo.

The paper introduces OASIS, a method to screen soluble ligands by enforcing autocrine signaling, and applies it to identify self-renewal factors in hiPSCs.

This paper introduces an RNA-based system called adaptamer that allows precise, reversible control of gene expression using small molecules, demonstrating its function in cell lines and mice.

This paper develops an RNA base editor using CRISPR-Cas13 and ADAR2DD to correct mutations in inherited retinal diseases, showing up to 60% editing efficiency in vitro and partial rescue in mouse models.

This study characterizes the transcriptomic effects of Cas13bt3 in retinal cells and demonstrates its efficacy in silencing VEGFA mRNA in human retinal organoids and mouse models.

This study evaluates RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce mis-spliced ABCA4 variants in Stargardt disease, showing significant reductions in disease-causing splice variants.