Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)
Patrik F. Schwarz, Alexander F. Perhal, Teresa Preglej, Lina Breit, Klaus G. Schmetterer, Ulrike Grienke, Jasmin Janneschütz, Ya Chen, Natacha Rochel, Johannes Kirchmair, Nina Schützenmeister, Judith Maria Rollinger, Michael Markus Bonelli, Verena Maria Dirsch
This study identifies primulagenin A as a potent inverse agonist of RORγ, showing efficacy in inhibiting Th17 cell differentiation and reducing IL-17A production.
Acta Pharmaceutica Sinica B · Mar 14, 2026Peer-reviewedPharmacology & Toxicology