Jing‐Dong J. Han

This study shows that cardiomyocytes can transition to a mesenchymal-like fate during myocardial fibrosis, regulated by HGS and ALDH1A2, contributing to fibrosis and calcification.

This paper develops a proteome-aware aging clock for multi-organ assessment using plasma proteomics, showing it correlates with physiological phenotypes and disease aging landscapes.

This paper identifies a novel metaphyseal skeletal stem cell (mpSSC) population derived from hypertrophic chondrocytes that supports trabecular bone formation.

The paper identifies a temporal genetic program in early neurogenesis, revealing molecular heterogeneity and gene expression dynamics in preplate and Cajal-Retzius neurons.

cLoops improves 3D genomic loop detection by analyzing paired-end tags directly, showing less distance bias and higher enrichment than existing tools.

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.