The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel B. Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Pardo, Lu Yu, Tanaji T. Talele, Jiří Bártek, Jyoti Sharma Choudhary, Yves G. Pommier, , Christopher J. Lord
The paper identifies p97 ATPase as a key player in removing trapped PARP1 from chromatin, enhancing PARPi-induced cytotoxicity in homologous recombination-defective cells.
Nature Cell Biology · Jan 1, 2022Peer-reviewedMolecular Biology