Mercedes Pardo

This study uses PRISMA to identify and map novel ARID1A interactions at high sequence resolution, revealing new interactors and a regulatory mechanism involving CDK2 phosphorylation.

This study shows ARID1A deficiency increases sensitivity to the G4 ligand pyridostatin due to impaired DNA repair, highlighting a role for ARID1A in G4 ligand-induced DNA damage responses.

The paper identifies 401 sex and transmission-related gene functions in malaria parasites through genetic screens, revealing conserved fertility mechanisms across eukaryotes.

The paper identifies pathway alterations and targetable vulnerabilities in SWI/SNF-defective cancers through multiomic profiling and drug screening.

The paper identifies ten genes critical for male and female sexual development in Plasmodium berghei and reveals a regulatory cascade governing gametogenesis.

The paper identifies p97 ATPase as a key player in removing trapped PARP1 from chromatin, enhancing PARPi-induced cytotoxicity in homologous recombination-defective cells.

CEDAR provides a database for complexome profiling data with standardized formats, a web interface, and tools for analysis and exploration.

The paper identifies 49 genes and pathways associated with osteoarthritis progression using integrative epigenomics, transcriptomics, and proteomics in human chondrocytes from OA patients.

The paper quantifies proteomic and genomic variation in colorectal cancer cell lines to understand how mutations affect protein levels and drug responses.