Author

James G. Xenakis

University of North Carolina at Chapel HillORCID 0000-0002-9307-9605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Approach:deep learning· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Fernando Pardo‐Manuel de VillenaiD· 3 shared Fei ZouiD· 2 shared Ginger D. ShawiD· 2 shared Martin T. FerrisiD· 2 shared Pablo Hock· 2 shared Timothy A. BelliD· 2 shared Alan C. Whitmore· 1 shared Allison Ryan· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Fernando Pardo‐Manuel de VillenaORCID

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4 papers

Recent·Most cited

A Deep Neural Network Two-part Model and Feature Importance Test for Semi-continuous Data

Baiming Zou, Xinlei Mi, Shiyu Wan, Di Wu, James G. Xenakis, Jianhua Hu, Fei Zou

This paper introduces a deep neural network-based two-part model for semi-continuous data and demonstrates its improved performance over existing methods.

The Annals of Applied Statistics · May 28, 2025Peer-reviewedBioinformatics

Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants

James E. Faber, Hua Zhang, James G. Xenakis, Timothy A. Bell, Pablo Hock, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Wojciech Rzechorzek

The paper identifies genetic variants associated with collateral blood vessel abundance in mice, linking them to potential human disease mechanisms.

Journal of Cerebral Blood Flow & Metabolism · Aug 12, 2023Peer-reviewedGenetics

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

Brea K. Hampton, Kenneth S. Plante, Alan C. Whitmore, Colton L. Linnertz, Emily A. Madden, Kelsey E. Noll, Samuel P. Boyson, Breantié Parotti, James G. Xenakis, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Mark T. Heise

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

PLoS Genetics · Dec 27, 2022Peer-reviewedGenetics

Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX)

Paola Giusti‐Rodríguez, James G. Xenakis, James J. Crowley, Randal J. Nonneman, Daniela M. DeCristo, Allison Ryan, Corey R. Quackenbush, Darla R. Miller, Ginger D. Shaw, Vasyl Zhabotynsky, Patrick F. Sullivan, Fernando Pardo‐Manuel de Villena, Fei Zou

This study identifies genetic factors influencing antipsychotic-induced adverse reactions in mice using RIX lines, finding strong strain and treatment interactions for behavioral phenotypes.

G3 Genes Genomes Genetics · Jul 21, 2020Peer-reviewedSystems Biology