Timothy A. Bell

Cross-coronavirus host susceptibility loci influence disease severity through immune mediators

The paper identifies immune mediators linking host susceptibility loci to disease severity across SARS-CoV and SARS-CoV-2 infections.

The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

Sarbecovirus disease susceptibility is conserved across viral and host models

The paper identifies a genetic locus associated with coronavirus disease susceptibility in mice and shows its relevance to human severe COVID-19 outcomes.

Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants

The paper identifies genetic variants associated with collateral blood vessel abundance in mice, linking them to potential human disease mechanisms.

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

Multi-omics analysis identifies drivers of protein phosphorylation

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

Host-pathogen genetic interactions underlie tuberculosis susceptibility

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

Regulation of protein abundance in genetically diverse mouse populations

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

Collaborative Cross Mouse Populations as a Resource for the Study of Epilepsy

The paper uses Collaborative Cross mice to identify genetic loci and candidate genes associated with epilepsy traits, providing resources for studying seizure outcomes and developing new therapies.

Instability of the pseudoautosomal boundary in house mice

The paper examines PAR boundary instability in house mice subspecies, showing high recombination rates and copy-number variation.

A diallel of the mouse Collaborative Cross founders reveals strong strain-specific maternal effects on litter size

The paper analyzes reproductive success in mouse Collaborative Cross founder strains, finding that dam strain has a larger effect on litter size than sire strain.

The evolutionary fates of a large segmental duplication in mouse

The paper reconstructs the evolutionary history of a segmental duplication in mice, showing gene conversion, structural variation, and meiotic drive associated with the duplication.

R2d2 drives selfish sweeps in the house mouse

The paper shows R2d2HC alleles drive selfish sweeps in house mice, increasing in frequency faster than genetic drift and reducing litter sizes in heterozygous mothers.