Fernando Pardo‐Manuel de Villena

The paper identifies immune mediators linking host susceptibility loci to disease severity across SARS-CoV and SARS-CoV-2 infections.

The paper identifies genetic loci affecting cocaine sensitivity in Collaborative Cross mouse strains through QTL mapping and proposes candidate genes for further study.

The paper examines sex-biased transcription of genes, lncRNAs, and TEs in four mouse organs, finding organ-specific patterns and clustering of sex-biased TEs near sex-biased genes and lncRNAs.

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

The paper identifies early high-amplitude rhythmic spikes in the hippocampus of mice after traumatic brain injury as predictive of post-traumatic epilepsy.

The paper identifies a genetic locus associated with coronavirus disease susceptibility in mice and shows its relevance to human severe COVID-19 outcomes.

This study identifies a Themis mutation as a genetic contributor to peanut-induced anaphylaxis in CC027 mice through genetic mapping and immunological analysis.

The paper identifies genetic variants associated with collateral blood vessel abundance in mice, linking them to potential human disease mechanisms.

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

This study examines population structure and inbreeding in wild house mice across five continents using SNP microarray data, revealing geographic patterns and high variability in inbreeding rates.

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

The paper assesses cocaine-induced locomotor activation in 20 inbred mouse substrains from six lineages, identifying significant phenotypic differences that could inform genetic studies of addiction.

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

The paper develops TReCASE, a statistical method for eQTL mapping using ASE data, showing it improves power and efficiency compared to existing methods.

The paper identifies genetic factors influencing immune cell populations in lung tissue and their predictive value for influenza outcomes in Collaborative Cross mice.

The paper uses Bayesian modeling to analyze XCI skew in genetically diverse mice, identifying a novel Xce allele linked to copy number changes.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

This study identifies genetic factors influencing antipsychotic-induced adverse reactions in mice using RIX lines, finding strong strain and treatment interactions for behavioral phenotypes.

The paper introduces a graph-based pangenome representation for the Collaborative Cross mouse genetic reference population, enabling analysis of multiple genomes in a unified framework.

The paper uses Collaborative Cross mice to identify genetic loci and candidate genes associated with epilepsy traits, providing resources for studying seizure outcomes and developing new therapies.

The paper examines PAR boundary instability in house mice subspecies, showing high recombination rates and copy-number variation.

The paper analyzes reproductive success in mouse Collaborative Cross founder strains, finding that dam strain has a larger effect on litter size than sire strain.

The paper investigates parent-of-origin effects and environment-by-POE on behavior and gene expression using reciprocal F1 hybrids of inbred mouse strains exposed to different diets.

The paper genetically analyzes invasive house mouse populations on two islands to understand their ancestry, inbreeding, and resistance alleles for eradication efforts.

EMASE improves ASE estimation by hierarchically allocating multi-mapping RNA-Seq reads, showing better performance than standard methods in simulations and detecting ASE in F1 hybrid mice.

The paper uses a diallel analysis in mice to study how host genetics affect response to influenza A virus, identifying Mx1-dependent and independent heritable effects on weight loss.

The paper examines sequence and copy number diversity of sex-linked genes in three mouse subspecies, finding reduced sequence diversity in non-repetitive regions consistent with positive selection during spermatogenesis.

The paper generates high-resolution genetic maps of mouse inbred strains and identifies genetic variations and gene conversions.

The paper reconstructs the evolutionary history of a segmental duplication in mice, showing gene conversion, structural variation, and meiotic drive associated with the duplication.