Samuel P. Boyson

The paper introduces hmSEEKR, a k-mer-based hidden Markov model that identifies non-linear sequence similarities in transcriptomes, revealing functional RNA domains with biological relevance.

The paper compares RNA-protein associations across lncRNAs Airn, Kcnq1ot1, and Xist, identifying HNRNPU's role in long-range Polycomb recruitment by Airn and Kcnq1ot1.

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

The paper shows that Airn lncRNA can deposit Polycomb with potency comparable to Xist when expressed at similar levels, but Xist is more potent when promoter activation is equal.

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

The paper shows that mRNA localization to P granules in C. elegans embryos is linked to translational repression, not just a downstream effect.