This study identifies a Themis mutation as a genetic contributor to peanut-induced anaphylaxis in CC027 mice through genetic mapping and immunological analysis.

bioRxiv · Sep 13, 2023 · PreprintGenetics

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

Brea K. Hampton, Kenneth S. Plante, Alan C. Whitmore, Colton L. Linnertz, Emily A. Madden, Kelsey E. Noll, Samuel P. Boyson, Breantié Parotti, James G. Xenakis, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Fernando Pardo‐Manuel de Villena, Martin T. Ferris, Mark T. Heise

The paper identifies MBD1 as a regulator of homeostatic IgG1 levels and marginal zone B cell differentiation through a genetic screen in Collaborative Cross mice.

PLoS Genetics · Dec 27, 2022Peer-reviewedGenetics

Host-pathogen genetic interactions underlie tuberculosis susceptibility

Clare M. Smith, Richard E Baker, Megan K. Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M. Bellerose, Andrew J. Olive, Kenan C. Murphy, Kadamba G. Papavinasasundaram, Frederick J. Boehm, Charlotte Jewell Reames, Rachel K. Meade, , Christopher M. Sassetti

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

eLife · Feb 3, 2022Peer-reviewedMicrobiology

Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice

Brea K. Hampton, Kara Jensen, Alan C. Whitmore, Colton L. Linnertz, Paul L. Maurizio, Darla R. Miller, Clayton R. Morrison, Kelsey E. Noll, Kenneth S. Plante, Ginger D. Shaw, Ande West, Ralph Steven Baric, Fernando Pardo‐Manuel de Villena, Mark T. Heise, Martin T. Ferris

The paper identifies genetic factors influencing immune cell populations in lung tissue and their predictive value for influenza outcomes in Collaborative Cross mice.

bioRxiv · Apr 9, 2021 · PreprintGenetics