David Lando

The paper shows that chromatin accessibility and co-factor availability determine ASCL1's ability to reprogram cells across different tissues in Xenopus embryos.

The paper uses human iPSC-derived 3D trunk-like structures to study mesodermal lineage decisions and identifies TBX6 and FOXC1/2 as key regulators in human trunk mesoderm diversification.

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

This study identifies high changing curvature (HCC) regions in Hi-C data that correlate with gene expression and CTCF density, showing cell-to-cell variability.