Jonathan H. Fox

The paper shows iron activates microglia and enhances IDO1 activity in HD mice, contributing to neurodegeneration via the kynurenine pathway.

This study shows that mutant huntingtin protein alters microglial responses to different inflammatory stimuli, reducing lipopolysaccharide-induced cytokines but increasing interleukin-6-induced nitric oxide.

This study shows that latent Toxoplasma gondii infection worsens neurodegeneration in YAC128 HD mice by increasing soluble mutant huntingtin and neurofilament light protein levels.