Jason P. Gigley

This study develops a gene expression system for intracellular L. monocytogenes that can be induced in vivo with a cumin derivative, showing significant reporter gene expression increases in tumors.

This study shows that CD4 co-receptor deficiency leads to faster death in female mice infected with T. gondii due to reduced IFN-gamma+ NK cells, but not in males.

The paper identifies transcriptomic differences in reward-specific ensembles in mice during cocaine and sucrose seeking using single-cell RNA sequencing.

The paper shows iron activates microglia and enhances IDO1 activity in HD mice, contributing to neurodegeneration via the kynurenine pathway.

This study shows that mutant huntingtin protein alters microglial responses to different inflammatory stimuli, reducing lipopolysaccharide-induced cytokines but increasing interleukin-6-induced nitric oxide.

This study shows that latent Toxoplasma gondii infection worsens neurodegeneration in YAC128 HD mice by increasing soluble mutant huntingtin and neurofilament light protein levels.